The Prime Minister Andy Burnham and Taoiseach (Irish PM) Micheál Martin will hold their first official meeting in Manchester on Friday.
Martin will be the first international leader to visit Number 10 North, the government said ahead of the talks.
The men are expected to discuss further strengthening of the UK/Ireland relationship including boosting trade, security and working with the EU.
Burnham said he was “delighted” to be hosting the taoiseach and said it was an “historic and proud day for Manchester”.
“No10 North is all about creating opportunities for working people, and our partnership with Ireland as we improve the lives of people in both of our countries is a key part of that,” he said.
“There is so much we can achieve together: from our shared commitment to the Good Friday Agreement, to trade, to working with Europe and supporting Ukraine. We are the closest of friends, and I look forward to further strengthening that friendship.”
Following their meeting, the leaders will visit a local Irish community centre to meet with representatives from the Irish community in Greater Manchester.
The visit comes days after US President Donald Trump made remarks supporting a “unified Ireland”.
On his visit to Northern Ireland last month, Burnham said a border poll was “off the table”, but later said he stood by the Good Friday Agreement.
It is also expected that the two leaders will discuss reform of the Stormont institutions as well as progress on replacing the controversial Troubles legacy act during their meeting.
