Met Éireann has issued an orange rain warning for County Kerry from 07:00 (local time) until 14:00 on Saturday.
The forecaster said Storm Boelo would bring spells of very heavy and intense rain, with flooding expected and damage to homes and businesses possible.
It warned of disruption and delays to rail and bus services, severe disruption to outdoor events and very difficult travelling conditions.
An orange wind warning has also been issued for Counties Donegal, Leitrim, Mayo and Sligo from 14:00 on Saturday until 09:00 on Sunday.
A yellow rain warning has been issued for Counties Clare, Cork, Donegal, Galway, Kerry, Leitrim, Limerick, Mayo and Sligo.
It will be in place from 04:00 until 15:00 on Saturday.
Met Éireann said spells of heavy rain could lead to localised flooding, difficult travelling conditions and disruption to outdoor events.
A yellow wind warning covering Counties Connacht, Clare, Kerry and Limerick will take effect at 13:00 on Saturday and remain in place until 12:00 on Sunday.
Very strong south-westerly winds are expected to turn westerly, bringing severe gusts and coastal gales.
The forecaster warned of large coastal waves, fallen trees and branches, displaced debris and difficult driving and cycling conditions.
A separate yellow wind warning for County Donegal will run from 13:00 on Saturday until 15:00 on Sunday, with similar impacts expected.
All five Met Éireann warnings were issued on Friday morning.
